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Candidate proteins that may mediate the susceptibility of neurons to abnormal protein accumulation. (A) A schematic outlining the datasets used to identify candidate proteins that may mediate the susceptibility of neurons to abnormal protein accumulation. See also Supplemental Tables S3, S6, and S13. (B) A model outlining the hypotheses that individuals with low basal proteasome activity are more susceptible to proteasome perturbation and prone to protein accumulation.
