TABLE 1.
Clinical demographic data for subjects used in this study.
| Sex (M/F) | Age (years) | Braak stage | APOE (E/E) | Onset | DS (years) | PMD (h:min) | Regions used | |
|---|---|---|---|---|---|---|---|---|
| For binding and immunoreactivity studies | ||||||||
| Control | ||||||||
| CN1 | F | 55 | 1 | 3/3 | 7:30 | FC, TC, PC, Cb | ||
| CN2 | M | 62 | 1 | 3/3 | 7:20 | FC, TC, PC, Hipp | ||
| CN3 | M | 72 | 2 | N/A | 4:20 | FC, TC, PC, Cb | ||
| *CN4 | M | 79 | 2 | 3/3 | 9:00 | FC | ||
| *CN5 | M | 81 | 2 | 3/3 | 7:55 | FC, TC, PC, Hipp, Cb | ||
| #CN6 | M | 82 | 2 | N/A | 5:55 | FC, TC, PC, Hipp, Cb | ||
| CN7 | F | 82 | 1 | 3/3 | 7:45 | FC, TC, PC, Cb | ||
| CN8 | M | 82 | 2 | N/A | 5:45 | FC, TC, PC, Cb | ||
| *CN9 | F | 84 | 1 | 3/3 | 6:55 | FC | ||
| #CN10 | F | 89 | 1 | N/A | 13:00 | FC, TC, PC, Cb | ||
| 6 M/4F | 76.8 ± 10.6 | 1—2 | 6 E3 0 E4 | 7.3 ± 2.4 | ||||
| AD | ||||||||
| AD1 | M | 62 | 6 | 4/3 | EOAD | 7–9 | 6:45 | FC, TC, PC, Cb |
| AD2 | F | 62 | 6 | 4/3 | EOAD | 7 | 4:45 | FC, TC, Cb |
| #AD3 | F | 64 | 6 | 4/3 | EOAD | 12 | 5:30 | FC |
| #AD4 | M | 68 | 6 | 4/3 | EOAD | 12 | 5:20 | FC |
| #AD5 | M | 77 | 6 | 4/4 | LOAD | 5 | 6:35 | FC |
| AD6 | M | 78 | 5 | 4/4 | LOAD | 7 | 6:35 | FC, TC, PC, Hipp, Cb |
| *AD7 | F | 79 | 5 | 4/4 | LOAD | N/A | 16:00 | FC |
| *AD8 | M | 81 | 5–6 | 4/4 | LOAD | N/A | 17:00 | FC |
| AD9 | F | 85 | 4 | 3/3 | LOAD | 5 | 6:00 | FC, TC, PC, Hipp |
| 5 M/ 4F | 72.8 ± 8.8 | 4–6 | 1 E3 8 E4 | 4EOAD 5LOAD | 8.0 ± 2.7 | 8.1 ± 4.8 | ||
| For large frozen section autoradiography studies | ||||||||
| Control a | F | 56 | N/A | 3/4 | 2:56 | |||
| sADa | F | 57 | N/A | 3/3 | EOAD | 8 | 2:48 | |
| sAD a | F | 79 | 5 | 4/4 | LOAD | N/A | 16:00 |
Note: All data are shown as means ± standard deviation (SD). * and # show CN and AD cases in pooled 1 and 2 samples used for saturation, competition, and immunoblot studies, respectively.
Abbreviations: APOE, apolipoprotein E; Cb, cerebellum; DS, symptom duration based on AD patient's clinical course information; EOAD, early‐onset Alzheimer's disease; FC, frontal cortex; F, female; Hipp, hippocampus; LOAD, late‐onset Alzheimer's disease; M, male, N/A, information not available; PC, parietal cortex; PMD, post‐mortem delay, sAD, sporadic Alzheimer's disease; TC, temporal cortex.