TABLE 2.
Results of mediation analyses for composite 11C‐PBR28 SUVR in AD progression model.
| X | Mediator | Y | Indirect effect (std. β, z, p) | Direct effect (std. β, z, p) | Total effect (std. β, z, p) |
|---|---|---|---|---|---|
| Global Aβ burden | Global TSPO expression | Tau in early Braak | 0.017, 0.195, .845 | 0.748, 5.259, .000 | 0.765, 6.895, 0.000 |
| Tau in early Braak | Neurodegeneration in early Braak | −0.157, −1.917, .055 | −0.229, −1.591, .112 | −0.386, −2.870, 0.004 | |
| Neurodegeneration in early Braak | Cognitive impairment – MMSE | 0.233, 2.307, .021 | 0.207, 1.310, .190 | 0.440, 2.821, 0.005 | |
| Cognitive impairment – SRT‐DR | 0.117, 1.536, .125 | 0.492, 3.368, .001 | 0.609, 4.553, 0.000 | ||
| Cognitive impairment – CF‐Animals | 0.076, 0.982, .326 | 0.391, 2.456, .014 | 0.468, 3.276, 0.001 | ||
| Cognitive impairment – Trails B | 0.283, 2.597, .009 | −0.057, −0.384, .701 | 0.226, 1.443, .149 | ||
| Tau in early Braak | Tau in middle Braak | 0.118, 2.169, .030 | 0.634, 7.078, .000 | 0.752, 8.750, .000 | |
| Tau in middle Braak | Neurodegeneration in middle Braak | −0.255, −2.214. .027 | −0.087, −0.506, .613 | −0.342, −2.295, .022 | |
| Neurodegeneration in middle Braak | Cognitive impairment – MMSE | 0.204, 2.185, .029 | 0.347, 2.277, .023 | 0.552, 3.768, .000 | |
| Cognitive impairment – SRT‐DR | 0.158, 1.794, .073 | 0.310, 1.959, .050 | 0.469, 3.198, .001 | ||
| Cognitive impairment – CF‐Animals | 0.061, 0.804, .422 | 0.454, 2.909, .004 | 0.515, 3.727, .000 | ||
| Cognitive impairment – Trails B | 0.228, 2.379, .017 | 0.211, 1.439, .150 | 0.439, 3.037, .002 | ||
| Tau in middle Braak | Tau in late Braak | 0.029, 0.956, .335 | 0.917, 18.22, .000 | 0.947, 23.03, .000 | |
| Tau in late Braak | Neurodegeneration in late Braak | −0.168, −1.382, .167 | 0.015, 0.077, .938 | −0.153, −0.966, .334 | |
| Neurodegeneration in late Braak | Cognitive impairment – MMSE | 0.0146, 1.588, .112 | 0.157, 1.074, .283 | 0.303, 1.850, .064 | |
| Cognitive impairment – SRT‐DR | 0.114, 1.497, .134 | 0.191, 1.283, .200 | 0.305, 1.933, .053 | ||
| Cognitive impairment – CF‐animals | 0.071, 1.251, .211 | 0.297, 1.983, .047 | 0.368, 2.450, .014 | ||
| Cognitive impairment – Trails B | 0.144, 1.603, .109 | 0.136, 1.003, .316 | 0.280, 1.180, .070 |
Note: Rows of significant mediations are shown in bold.
Abbreviations: CF, categorical fluency; MMSE, Mini‐Mental State Examination; SRT‐DR, Selective Reminding Test‐Delayed Recall; std, standardized; SUVR, standardized uptake value ratio; TSPO, translocator protein.