TABLE 1.
Characteristics of study cohorts.
| LLFS | Replication datasets | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| All | Proband | Offspring | NIA‐FBS | ABC‐DS | omicsADDS | ROSMAP | ADGC | WHICAP | |
| N | 3475 | 1303 | 2172 | 4079 | 336 | 244 | 912 | 6977 | 851 |
| Percentage of women | 55 | 53 | 56 | 61 | 46 | 65 | 66 | 57 | 60 |
| Age (mean ± SD) | 71 ± 16 | 89 ± 7 | 61 ± 8 | 74 ± 11 | 46 ± 10 | 56 ± 7 | 89 ± 6 | 79 ± 8 | 81 ± 7 |
| Education (mean ± SD) | 14 ± 3 | 13 ± 2 | 16 ± 3 | 14 ± 3 | – | – | 16 ± 4 | 16 ± 3 | 14 ± 4 |
| Prevalence of LOAD (%) | 7 | 15 | 2 | 60 | 21 | 28 | 69 | 48 | 21 |
Abbreviations: ABC‐DS, Alzheimer's Biomarkers Consortium‐Down Syndrome; ADGC, Alzheimer's Disease Genetic Consortium; LLFS, Long‐Life Family Study; LOAD, late‐onset Alzheimer's disease; NIA‐FBS, The National Institute on Aging Alzheimer's Disease Family Based Study; omicsADDS, The Multiomic Studies of Alzheimer's Disease in Adults with Down Syndrome Study; ROSMAP, the Religious Orders Study/Memory and Aging Project; WHICAP, the Washington Heights/Inwood Columbia Aging Project.
a
As described in the manuscript, educational levels are not available for both Down Syndrome cohorts.