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. 2024 Mar 7;20(4):2861–2872. doi: 10.1002/alz.13749

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© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Standardized estimates. This plot displays the standardized beta (dot) and the 95% confidence interval (95% CI; error bars) for the association with postoperative delirium of four diffusion kurtosis imaging (DKI) metrics: mean diffusivity (MD), fractional anisotropy (FA), mean kurtosis (MK) and free water (FW). There are three time points for each metric: preoperative (preop.), 3 months after surgery (postop. 3m), and 12 months after surgery (postop. 12m). Covariates were age, sex, Charlson Comorbidity index, baseline Mini‐Mental State Examination, and scanner type. Baseline DKI metrics were further added to the two postsurgical analyses. Of note, after correction for multiple testing postoperative FW and MK (postop. 3m) were not significantly associated with postoperative delirium.