. 2024 Mar 7;20(4):2861–2872. doi: 10.1002/alz.13749

TABLE 2.

Regional associations of POD with preoperative white matter abnormalities compared to patients without POD as indicated by interaction of JHU atlas region and POD.

Metric	Region	Hemisphere	JHU atlas number	B ± SE	p
MD	Genu corpus callosum		3	0.000046 ± 0.000019	0.01289
	Body corpus callosum		4	0.000041 ± 0.000019	0.02955
	*Fornix*		6	*0.00014* ± *0.000019*	<0.00001
	Sup. Cerebellar peduncle	R	13	0.000047 ± 0.000019	0.01163
	Ant. Corona radiata	R	24	0.000046 ± 0.000019	0.01378
	*Fornix/Stria terminalis*	R	39	*0.000061* ± *0.000019*	*0.00122*
	Sup. Frontoocc. Fsc.	R	43	0.000050 ± 0.000019	0.00797
	*Sup. Frontoocc. Fsc* .	L	44	*0.000091* ± *0.000019*	<0.00001
	*Tapetum*	L	48	*0.000084* ± *0.000019*	<0.00001
FW	Genu corpus callosum		3	0.011 ± 0.005	0.03696
	Sup. Frontoocc. Fsc.	R	43	0.011 ± 0.005	0.03559
	Uncinate fsc.	L	46	−0.011 ± 0.005	0.03618
	Tapetum	L	48	−0.012 ± 0.005	0.01537
FA	*Genu corpus callosum*		3	− **0.016 ± 0.006**	*0.00392*
	*Fornix*		6	− **0.020 ± 0.006**	*0.00035*
	Post. limb of int. capsule	R	19	0.013 ± 0.006	0.01734
	*Cingulate gyrus*	L	36	− **0.016 ± 0.006**	*0.00386*
	Fornix/stria terminalis	R	39	−0.013 ± 0.006	0.02343
	Fornix/stria terminalis	L	40	−0.013 ± 0.006	0.02229
MK	Ant. corona radiata	L	24	−0.023 ± 0.010	0.02685
	Superior corona radiata	R	25	−0.022 ± 0.010	0.03592
	Superior corona radiata	L	26	−0.021 ± 0.010	0.04917
	Cingulum (hippocampus)	R	37	0.023 ± 0.010	0.02441
	*Sup. Frontoocc. Fsc* .	L	44	− **0.056 ± 0.010**	<0.00001
	Uncinate fasciculus	L	46	−0.026 ± 0.010	0.01428

Note: Regions with more pronounced effects as estimated from the global association are highlighted in bold/italic. The table illustrates results for preoperative data. The number of POD by region interactions was reduced using backward stepwise regression removing interactions using a significance criterion of p > 0.05. Please note that the corrected alpha‐level was p < 0.0042. The significant regions are in bold letters.