TABLE 4.
Regional associations of POD with postoperative white matter alterations at follow‐up 12 months after surgery as indicated by interaction of JHU atlas region and POD.
| Metric | Region | Hemisphere | JHU atlas number | B ± SE | p |
|---|---|---|---|---|---|
| MD | Ant. limb of. int. capsule | L | 18 | 0.00013 ± 0.00004 | 0.00043 |
| Ant. corona radiata | L | 24 | 0.00017 ± 0.00004 | <0.00001 | |
| Fornix/stria terminalis | R | 39 | 0.00011 ± 0.00004 | 0.00414 | |
| Fornix/stria terminalis | L | 40 | 0.00009 ± 0.00004 | 0.01570 | |
| Sup. frontoocc. Fsc . | L | 44 | 0.00014 ± 0.00004 | 0.00011 | |
| FW | Fornix/stria terminalis | L | 40 | 0.029 ± 0.017 | 0.03360 |
| Tapetum | R | 47 | 0.029 ± 0.017 | 0.03754 | |
| Tapetum | L | 48 | −0.037 ± 0.014 | 0.00724 | |
| FA | Cingulum (hippocampus) | L | 38 | 0.024 ± 0.012 | 0.03692 |
| Tapetum | R | 47 | −0.023 ± 0.012 | 0.04590 | |
| MK | Corticospinal tract | L | 8 | −0.056 ± 0.026 | 0.03428 |
| Sup. Cerebellar peduncle | R | 13 | 0.107 ± 0.026 | <0.00001 | |
| Cerebral peduncle | L | 16 | −0.073 ± 0.027 | 0.00597 |
Note: Regions with more pronounced effects as estimated from the global association are highlighted in bold/italic. The table illustrates results for the 12 months follow‐up. The number of POD by region interactions was reduced using backward stepwise regression removing interactions using a significance criterion of p > 0.05. Please note that the corrected alpha‐level was p < 0.0042. The significant regions are in bold letters.