Table 2.
Primary Outcomes and Secondary Outcomes
| Characteristics | Unadjusted Outcome Variable Value (95% CI) | P value | Adjusted Value (95% CI) | P value |
|---|---|---|---|---|
| Primary Efficacy Outcomes | ||||
| Modified Rankin Scale score at 90d, median (IQR) | ||||
| Mean temperature Onset to groin puncture (°C) | 1.013(1.004–1.022) | 0.004 | 1.006(0.997–1.016) | 0.179 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 1.349(1.009–1.804) | 0.044 | 1.311(0.968–1.776) | 0.080 |
| Warm group (19.79–29.83) | 1.499(1.121–2.003) | 0.006 | 1.386(1.024–1.878) | 0.035 |
| Hot group (≥29.84) | 1.472(1.022–2.119) | 0.038 | 1.254(0.856–1.838) | 0.246 |
| Secondary Efficacy Outcomes | ||||
| mRS 90d, 0–3 | ||||
| Mean temperature Onset to groin puncture (°C) | 1.011(1.001–1.021) | 0.038 | 1.005(0.993–1.018) | 0.407 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 1.290(0.930–1.790) | 0.127 | 1.234(0.833–1.828) | 0.293 |
| Warm group (19.79–29.83) | 1.510(1.089–2.095) | 0.014 | 1.474(0.994–2.185) | 0.053 |
| Hot group (≥29.84) | 1.367(0.902–2.072) | 0.141 | 1.189(0.725–1.947) | 0.493 |
| mRS 90d, 0–2 | ||||
| Mean temperature Onset to groin puncture (°C) | 1.016(1.006–1.027) | 0.002 | 1.016(1.004–1.029) | 0.009 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 1.366(0.968–1.928) | 0.076 | 1.322(0.889–1.965) | 0.168 |
| Warm group (19.79–29.83) | 1.599(1.134–2.254) | 0.007 | 1.646(1.107–2.448) | 0.014 |
| Hot group (≥29.84) | 1.520(0.988–2.339) | 0.057 | 1.460(0.890–2.394) | 0.134 |
| mRS 90d, 0–1 | ||||
| Mean temperature Onset to groin puncture (°C) | 1.007(0.996–1.018) | 0.233 | 1.005(0.993–1.018) | 0.406 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 1.285(0.885–1.866) | 0.187 | 1.232(0.810–1.875) | 0.330 |
| Warm group (19.79–29.83) | 1.286(0.886–1.867) | 0.186 | 1.267(0.832–1.929) | 0.270 |
| Hot group (≥29.84) | 1.157(0.722–1.853) | 0.544 | 1.087(0.640–1.845) | 0.757 |
| Safety outcomes | ||||
| Symptomatic intracranial hemorrhage, No. (%) | ||||
| Mean temperature Onset to groin puncture (°C) | 0.995(0.976–1.014) | 0.596 | 0.997(0.977–1.018) | 0.802 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 1.062(0.579–1.940) | 0.847 | 0.960(0.514–1.794) | 0.898 |
| Warm group (19.79–29.83) | 0.922(0.499–1.703) | 0.795 | 0.877(0.466–1.651) | 0.684 |
| Hot group (≥29.84) | 0.719(0.310–1.664) | 0.440 | 0.726(0.307–1.715) | 0.465 |
| Complications after cerebral infarction, No. (%) | ||||
| Pneumonia | ||||
| Mean temperature Onset to groin puncture (°C) | 0.985(0.975–0.996) | 0.005 | 0.992(0.981–1.003) | 0.170 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 1.092(0.781–1.527) | 0.606 | 1.271(0.884–1.828) | 0.196 |
| Warm group (19.79–29.83) | 0.853(0.611–1.191) | 0.350 | 1.016(0.707–1.459) | 0.933 |
| Hot group (≥29.84) | 0.765(0.502–1.165) | 0.211 | 0.952(0.604–1.503) | 0.834 |
| Mortality at 90 days, No. (%)* | ||||
| Mean temperature Onset to groin puncture (°C) | 0.984(0.973–0.995) | 0.004 | 0.992(0.979–1.005) | 0.208 |
| Cold group (≤6.47) | Reference | NA | Reference | NA |
| Cool group (6.48–19.78) | 0.727(0.515–1.026) | 0.070 | 0.717(0.478–1.076) | 0.109 |
| Warm group (19.79–29.83) | 0.633(0.447–0.896) | 0.010 | 0.667(0.444–1.004) | 0.052 |
| Hot group (≥29.84) | 0.569(0.359–0.902) | 0.016 | 0.653(0.381–1.118) | 0.120 |
Note: *All cause death.
Abbreviations: IQR, interquartile range; CI, Confidence Interval; mRS, Modified Rankin Scale score.