Table 1.
Identity of clones isolated by serological screening
| Gene identified/accession no. | Positive clones (n) | Functional significance | Expression pattern | Identical and related entries in the SEREX database |
|---|---|---|---|---|
| Activation transcription factor 2/X15875 | 4 | Oncogenic AP1- transcription factor, interacts with c-myc and EBV | Ubiquitously expressed | One entry for ATF-3/NM_001674 (breast cancer) |
| Nm23-H2/NM_002512 | 3 | Nucleoside diphosphate kinase/transcription factor for c-myc | Overexpressed in tumours | Two entries for Nm23-H2 (glioma and colon cancer), two further entries for Nm23-H1(NM_000269) |
| S-adenosylhomocysteine hydrolase/M61831 | 1 | Hydrolase involved in transmethylation | Ubiquitously expressed | One entry for AHCYNM_000687 (cDNA from testis, unclassifiable patient) |
| Triosephosphate isomerase 1/NM_000365 | 1 | Enzyme of the glycolytic pathway | Overexpressed in tumours | Three entries for TPI1 (unclassifiable patient and breast cancer) |
| U2 snRNP-specific A′ protein/X13482 | 1 | Role in hnRNA splicing/known autoantigen | Ubiquitously expressed | Four entries for U2 small nuclear ribonucleo-protein auxiliary factor/NM_005089 (renal cancer, breast cancer, stomach cancer, and Hodgkin’s disease) |
| Ribosomal protein S2/NM_002952 | 1 | Ribosomal protein | Ubiquitously expressed | Two entries for ribosomal protein S2 (rps2) in prostate cancer |
| Unknown/AA195197 | 1 | Endogenous retroviral sequence? | No entry with similarity |