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Novel IFN-α formulations
| IFN-α species | Molecular characteristics | Doses | Advantages vs conventional formulation |
|---|---|---|---|
| Pegylated IFN-α-2a (Pegasys) | 40-kDa branched polyethylene glycol (PEG) | 450-μg weekly administration | Allows protracted tumour cell exposure |
| Improves patient compliance | |||
| Reduces toxicity | |||
| Pegylated IFN-α-2b (Peg-Intron A) | 12-kDa monomethoxy PEG | 7.5 μg/kg weekly administration | Allows protracted tumour cell exposure |
| Improves patient compliance | |||
| Reduces toxicity |
