Table 2.
Results of microarray analysis following rituximab stimulation (DHL4)
| Gene | GenBank accession number | Fold increase | Mean fold change (SD) | Mean p value for changea | Mean signal (SD) | Functionb | ||
|---|---|---|---|---|---|---|---|---|
| Experiment 1 (4 h) | Experiment 2 (4 h) | Experiment 3 (8 h) | ||||||
| RGS2 (GOS8) | L13463 | 8.6 | 3.7 | 4.0 | 5.4 (2.7) | <0.0001 | 1,425 (752) | ST |
| DUSP2 (PAC1) | NM_004418 | 11.3 | 2.6 | 5.3 | 6.4 (4.4) | <0.0001 | 1,240 (691) | ST |
| ETR101 | NM_004907 | 3.7 | 6.1 | 3.7 | 4.5 (1.3) | <0.0001 | 1,343 (543) | ST |
|
NR4A1 (TR3) 2 probe setsc |
L13740 | 9.2 | 7.5 | 2.3 | 4.7 (3) | <0.0001 | 368 (164) | TF |
| 4.0 | 3.5 | 1.7 | ||||||
| ZFP36 | NM_003407 | 2.8 | 3.7 | 3.3 | 3.3 (0.5) | <0.0001 | 502 (231) | TF |
| MAPK6 (Erk3) | NM_002748 | 2.5 | 2.1 | 2.0 | 2.2 (0.2) | <0.0001 | 240 (37) | ST |
| JunB | NM_002229 | 4.9 | 3.0 | 2.6 | 3.5 (1.2) | <0.0001 | 306 (56) | TF |
| FOS | NM_005252 | 29.9 | 2.5 | 14.9 | 15.8 (13.7) | 0.0003 | 47 (11) | TF |
| DDIT3 (GADD153)2 probe setsc | NM_004083 | 5.3 3.7 | 24.3 5.3 | 11.3 5.7 | 9.3 (7.8) | <0.0001 | 731 (563) | TF |
| ID3 | NM_002167 | 2.8 | 3.7 | 2.8 | 3.1 (0.5) | <0.0001 | 987 (326) | TF |
| TIEG | NM_005655 | 3.7 | 2.3 | 3.0 | 3.0 (0.7) | <0.0001 | 212 (72) | TF |
| ZFP36L1 (Erf1) | NM_004926 | 2.5 | 4.0 | 2.3 | 2.9 (0.9) | 0.0008 | 386 (82) | TF |
| DSIPI | NM_004089 | 12.1 | 4.3 | 3.7 | 6.7 (4.7) | <0.0001 | 213 (67) | TF |
| VEGF | NM_003376 | 2.1 | 3.0 | 2.0 | 2.4 (0.6) | <0.0001 | 320 (185) | SP |
| CD83 (HB15) | NM_004233 | 2.6 | 2.5 | 2.3 | 2.5 (0.2) | <0.0001 | 430 (73) | MP |
| INSIG1 | NM_198336 | 2.0 | 2.6 | 2.1 | 2.3 (0.3) | <0.0001 | 703 (256) | MP |
ap Values for change were obtained as described in the Affymetrix Data Analysis Fundamentals manual (http://www.affymetrix.com)
b ST signal transduction protein, TF transcription factor/DNA-RNA regulator, MP membrane, SP secreted protein
cFor DDIT3 and NR4A1, the results obtained with two different probe sets are shown. Mean fold induction and mean signals in this case refer to both probe sets