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Examples of CARs. CARs interact with their antigen (Ag)-binding regions of Ig (scFv-α-Ag) that consist of VH and VL chains linked by a short peptide linker. CD8 α chain functions in many cases as a flexible linker. CARs also incorporate the transmembrane (TM) and intracellular (IC) signaling domains of the Fcγ, TCR, and CD28, as shown
