Table 1.

Tumor antigens targeted by lymphocytes grafted with CARs containing various signaling units

Signaling molecule	Recognition unit	Target antigen	References
TCR-ζ	Fab or scFv	HER-2/neu	[27, 28, 44, 48]
		CEA	[1, 78, 81]
		TAG-72	[71]
		GD3	[42]
		PSMA	[81]
		EGP2	[76]
		GD2	[82]
		CD19	[74]
FcɛRI-γ	scFv	CEA	[45, 69]
		EGP40	[83]
		FBP	[72, 73]
		G250	[37, 84]
		EGP2	[76]
PTK	scFv	TNP	[23]
TCR-ɛ	Fab	GD3	[42]
CD28	scFv	GD2	[85]
TCR-ζ and CD28	scFv	CEA	[30]
		PSMA	[59]
		HER-2/neu	[1]