Table 4.
Novel RCC-associated antigens identified by overexpression and the source of HLA ligands presented by several allotypes
| Source protein overexpression > threefold in X/11 RCCs | Entrez Gene ID | Sequence | HLA restriction | References |
|---|---|---|---|---|
| Apolipoprotein L, 1 (APOL1) 9/11 (M 7.1; R 1.1–40.2) | 8542 | FLGENISNFL | A*0201 | [11, 56] |
| ALADGVQKV | A*0201 | [11, 56] | ||
| Insulin-like growth factor binding protein 3 (IGFBP3) 8/11 (M 6.0; R 2.0–10.2) | 3486 | RPTLWAAAL | B*07 | |
| Regulator of G-protein signalling 5 (RGS5) 7/11 (M 7.2; R 0.3–14.9) | 8490 | GLASFKSFLK | A*03 | |
| LAALPHSCL | A*02 | |||
| Matrix metalloproteinase 7, matrilysin (MMP7) 4/11 (M 2.4; R 0.3–12.1) | 4316 | FPNSPKWTSK | A*03 | |
| SLFPNSPKWTSK | A*03 | |||
| Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) 3/11 (M 0.6; R 0.3–9.2) | 1545 | FLDPRPLTV | A*02 | |
| Acyl-CoA synthetase long-chain family member 4 (ACSL4) 1/11 (M 1.3; R 0.8–7.1) | 2182 | KLFDHAVSKF | A*03 | |
| VPNQKRLTLL | B*07 |
M median; R range of overexpression