Fig. 6a,b.
TCR-transgenic SCID mice reject F9 cells transduced to express FLIP. a Id-specific TCR-transgenic SCID (lines) or SCID littermates (dots) were injected with the indicated numbers of tumor cells s.c. between the shoulder blades. F9MFL10.7.1 cells express FLIP; F9M8.18 cells have been transfected with vector alone. b A single tumor cell suspension obtained from a SCID mouse with a 1.4-cm s.c. FLIPL F9 tumor (F9MFL10.7.1) was grown in vitro for 10 days and tested for sensitivity to titrated amounts of agonistic anti-Fas mAb Jo2 and isotype-matched control UC8