Table 2.

Evidence indicating cancer immune surveillance in murine models

Model	Mechanism	References
Fibrosarcoma model in immunocompetent and nude mice	Immune selection or H-2 class I–negative variant in immunocompetent mice versus nude mice	[16, 17]
RAG2-deficient mice; RAG2 × STAT1–deficient mice	High incidence of MCA-induced sarcomas and spontaneous intestinal and mammary neoplasia	[52]
Nude and SCID mice	More immunogenicity of MCA-induced sarcomas derived from nude and SCID mice	[13, 58]
RAG1-deficient mice SCID mice	High incidence of MCA-induced sarcomas	[54]
Immunocompetent mice	Immune selection of TAP1-negative tumor cells	[30]
Perforin-deficient mice	High incidence of MCA-induced sarcomas and spontaneous disseminated lymphomas	[53, 62]
IFN-γ–deficient mice	High incidence of MCA-induced sarcomas, spontaneous disseminated lymphomas, and spontaneous lung adenocarcinomas	[32, 52, 56]
LMP2-deficient mice	High incidence of spontaneous uterine neoplasia	[28]
TCRδ-deficient mice	High incidence of MCA-induced sarcomas; DMBA/TPA-induced skin tumors	[15, 23, 24]