Fig. 8.

Sera of BALB-neuT–vaccinated mice have specific anti-p185neu antibodies able to down-regulate rat p185neu from the membrane of TUBO cells. When TUBO cells are incubated with Abs specific for p185neu at 37°C the receptor is internalized while at 4°C the down-regulation is blocked, as indicated by confocal microscopy studies. Their activity appears to be similar to that of passively administered anti-rat p185neu monoclonal antibodies