Fig. 6.

Possible model of IL-12 and TNF-α secretions through IL-12/TNF-α/NF-κB autocrine loop. NF-κB activation is induced in Mo-DCs-Tum (step 1). NF-κB activation induces secretion of both TNF-α and IL-12 (step 2). Both IL-12 and TNF-α secretions induce further NF-κB activation (step 3). Enhanced NF-κB activation induces further secretion of IL-12 and TNF-α. Thus, IL-12, TNF-α, and NF-κB form an autocrine loop in Mo-DCs-Tum