Table 2.
Multivariable Cox regression results for the association of C-reactive protein with survival outcomes for the DACHS and UK Biobank cohorts
| Outcome | DACHS cohort |
Ptrend | UK Biobank cohort |
Ptrend | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| C-reactive protein serum level |
C-reactive protein serum level |
|||||||||
| <3 mg/l | 3-5 mg/l | 5-10 mg/l | ≥10 mg/l | <3 mg/l | 3-5 mg/l | 5-10 mg/l | ≥10 mg/l | |||
| Overall survival | ||||||||||
| No. at risk/events | 754/315 | 165/73 | 223/129 | 274/171 | 712/159 | 181/50 | 150/51 | 106/51 | ||
| Model 1 HR (95% CI)a | Ref | 1.26 (0.97-1.63) | 1.76 (1.42-2.18) | 2.01 (1.65-2.45) | <0.001 | Ref | 1.26 (0.92-1.74) | 1.69 (1.23-2.31) | 2.70 (1.96-3.71) | <0.001 |
| Model 2 HR (95% CI)b | Ref | 1.08 (0.83-1.40) | 1.66 (1.34-2.07) | 1.93 (1.58-2.35) | <0.001 | — | — | — | — | — |
| CRC-specific survival | ||||||||||
| No. at risk/events | 754/126 | 165/38 | 223/63 | 274/105 | 712/130 | 181/32 | 150/35 | 106/41 | ||
| Model 1 HR (95% CI)a | Ref | 1.50 (1.03-2.18) | 1.98 (1.44-2.72) | 2.92 (2.22-3.86) | <0.001 | Ref | 1.00 (0.67-1.47) | 1.47 (1.02-2.12) | 2.61 (1.83-3.72) | <0.001 |
| Model 2 HR (95% CI)b | Ref | 1.17 (0.81-1.71) | 1.79 (1.30-2.47) | 2.70 (2.03-3.59) | <0.001 | — | — | — | — | — |
Values shown in bold are statistically significant (P value < 0.05).
CI, confidence interval; HR, hazard ratio; Ref, reference; TNM, tumour–node–metastasis.
a
Model 1: Adjusted for sex, age, body mass index, alcohol consumption, smoking status, physical exercise, history of cardiovascular disease (heart failure, myocardial infarction, angina pectoris, stroke), history of diabetes, history of hypertension, vitamin D status and season of blood draw.
b
Model 2: Adjusted for model 1 + TNM stage.