Figure 7.

Aqueous-enriched cytokines and their receptors are broadly expressed. A, Violin plots mRNA expression of cytokines by aqueous immune cells. Gene expression was pseudobulked by patient, and each dot represents a single patient. Potential ligand-receptor pairs were identified based on cell type-specific gene expression using SingleCellSignalR. B, Network plot showing cytokine signaling among immune cells of the aqueous fluid. Cell types are indicated by the color of the icon. Chevron icons indicate receptor genes and diamond icons indicate ligand genes. cDC = conventional dendritic cell; IL = interleukin; NK = natural killer; pDC = plasmacytoid dendritic cell; TNF = tumor necrosis factor.