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. 2024 Apr 12;72:103157. doi: 10.1016/j.redox.2024.103157

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© 2024 The Authors

This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Fig. 4 — Cardiomyocyte-specific knockout of METTL3 attenuates DOX-induced cardiac ferroptosis. (A) Relative mRNA levels of Ptgs2 in heart tissues of METTL3^fl/fl and METTL3^CKO mice (n = 6 per group). (B) Representative immunohistochemical images stained with 4-hydroxynonenal (4-HNE), and quantitative analysis of 4-HNE-positive area (n = 5 per group). (C) ELISA quantification of 4-HNE adducts in heart tissues of METTL3^fl/fl and METTL3^CKO mice (n = 6 per group). (D) Malondialdehyde (MDA) levels in heart tissues (n = 5 per group). (E) GSH/GSSG levels in heart tissues (n = 5 per group). (F)-(H) Protein levels of GPX4 and SLC7A11 in heart tissues (n = 6 per group); (I) Representative electron microscopy images of mitochondria in heart tissues. Mean ± SEM. P values were determined by one-way ANOVA with Tukey's post-hoc test (A-E, G and H).*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.