Table 1.
Patient characteristics
| WiN persistent <30 IU/dL n = 188 |
WiN partially corrected 30-50 IU/dL n = 121 |
WiN normalized >50 IU/dL n = 94 |
LoVIC n = 162 |
P | |
|---|---|---|---|---|---|
| Age at diagnosis, y | 23.3 ± 19.0 | 26.5 ± 17.3 | 25.1 ± 17.7 | 32.5 ± 13.5 | <.001 |
| Age at enrollment, y | 39.3 ± 19.9 | 39.4 ± 18.5 | 41.2 ± 20.3 | 39.2 ± 13.5 | .532 |
| Time between diagnosis and enrollment | 16.0 ± 14.3 | 13.0 ± 10.0 | 15.5 ± 11.2 | 6.9 ± 6.9 | <.001 |
| Female sex | 119 (63.3%) | 84 (69.4%) | 65 (69.1%) | 144 (88.9%) | <.001 |
| Blood group O | 115 (61.8%) | 92 (76.0%) | 68 (73.1%) | 145 (91.8%) | <.001 |
| Reason for referral | |||||
| Positive family history | 109 (62.6%) | 37 (32.2%) | 22 (25.6%) | 40 (24.0%) | <.001 |
| Bleeding history | 62 (35.6%) | 70 (60.9%) | 61 (70.9%) | 78 (46.7%) | |
| Both family history and bleeding | 12 (7.2%) | ||||
| Incidental findings | 3 (1.7%) | 8 (7.0%) | 3 (3.5%) | 37 (22.2%) | |
| VWF sequence variants | 120 (93.0%) | 39 (53.4%) | 14 (22.6%) | 44 (36.4%) | <.001 |
| Age at desmopressin trial, y | 31.8 ± 16.1 | 36.0 ± 13.9 | 41.9 ± 13.8 | 32.9 ± 10.7 | <.001 |
Data are presented as mean ± standard deviation or number (%).
P values are outcomes of analysis of variance or χ2 tests.