Table 1.
Genome-wide significant independent loci of GWAS meta-analysis for severe GT
| CHR | BP | SNP | A1 | A2 | EAF | Gene | Consequence | Effect | Meta-analysis |
Longgang |
Baoan |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||||||||
| 1 | 156 899 255 | rs12566888 | G | T | 0.5868 | PEAR1 | intron_variant | MODIFIER | 2.00 (1.69-2.38) | 1.07 × 10–15 | 2.17 (1.75-2.70) | 2.79 × 10–12 | 1.78 (1.35-2.32) | 4.35 × 10–5 |
| 20 | 59 022 916 | rs415064 | C | G | 0.0888 | TUBB1 | missense_variant | MODERATE | 1.91 (1.59-2.28) | 2.08 × 10–12 | 2.01 (1.61-2.51) | 7.37 × 10–10 | 1.72 (1.27-2.34) | 4.97 × 10–4 |
A1, effect allele; A2, noneffect allele; BP, base pair position; CHR, chromosome; EAF, effect allele frequency.