Table 4.

Network pharmacology research on TCM interventions for gastric inflammation-induced tumorigenesis

Formula	Lesion	Research strategy	Mechanism of action	Refs
Huangqi Jianzhong Tang	CAG	Network pharmacology and metabolomics	Mitochondrial energy metabolism regulation	108
Qilianshupi decoction	CAG	Network pharmacology and in vivo validation	Survivin and p53 inhibition; regulation of telomerase activity and telomere length	109
Modified Sijunzi decoction	CAG	Network pharmacology and clinical trial	T-cell receptor beta regulation	110
Huazhuojiedu decoction	CAG	Network pharmacology and in vivo validation	Cancer-associated AKT1 pathway inhibition	111
Moluodan	CAG	Network pharmacology and in vitro validation	Inhibition of cell proliferation; promotion of cell differentiation and apoptosis; decreased inflammation; increased lipid droplet accumulation	104
Banxia Xiexin decoction	CAG	Network pharmacology and in vitro dynamic validation	Gastrin and MAPK signaling pathway regulation	112
Manpixiao decoction	LGD	Network pharmacology and in vivo validation	EGFR-PI3K-Akt-associated EMT pathway downregulation	113
Weifuchun capsule	CAG	Network pharmacology and omics data and algorithms, and in vitro validation	Inhibition of inflammatory cytokines; regulation of immune cells, such as T cells and macrophages; inflammation inhibition	107