Table 5.
Genera with significant differences in comparison between HCV post-SVR CH and HCV post-SVR LC on each site.
| Site | Genera | Relative abundance in Control | Relative abundance in HCV post-SVR CH | Relative abundance in HCV post-SVR LC | p-value* | p-value* |
|---|---|---|---|---|---|---|
| (mean ± SD) | (mean ± SD) | (mean ± SD) | Ctrl vs LC | CH vs LC | ||
| Terminal ileum |
Bilophila | 0.22 ± 0.25 | 0.24 ± 0.24 | 0.10 ± 0.16 | 0.198 | 0.042 |
| Atopobium | 0.16 ± 0.27 | 0.08 ± 0.11 | 0.52 ± 0.72 | 0.074 | 0.022 | |
| Anaerotignum | 0.16 ± 0.16 | 0.30 ± 0.29 | 0.07 ± 0.10 | 0.048 | 0.016 | |
| Coprobacter | 0.06 ± 0.12 | 0.13 ± 0.24 | 0.01 ± 0.01 | 0.619 | 0.031 | |
| Holdemania | 0.03 ± 0.04 | 0.05 ± 0.06 | 0.02 ± 0.05 | 0.144 | 0.029 | |
| Ascending colon |
Blautia | 6.07 ± 3.80 | 8.72 ± 5.76 | 2.27 ± 2.31 | 0.002 | 0.002 |
| Alistipes | 1.12 ± 1.13 | 1.58 ± 1.69 | 0.34 ± 0.47 | 0.009 | 0.022 | |
| Dorea | 1.07 ± 0.99 | 0.77 ± 0.60 | 0.20 ± 0.42 | 0.003 | 0.031 | |
| Roseburia | 0.82 ± 0.91 | 1.38 ± 1.03 | 0.42 ± 0.58 | 0.154 | 0.013 | |
| Sporobacter | 0.63 ± 0.97 | 0.13 ± 0.22 | 0.06 ± 0.11 | 0.001 | 0.016 | |
| Pseudoflavonifractor | 0.50 ± 0.31 | 0.73 ± 0.63 | 0.24 ± 0.38 | 0.003 | 0.022 | |
| Agathobaculum | 0.44 ± 0.30 | 0.70 ± 0.54 | 0.17 ± 0.29 | 0.004 | 0.003 | |
| Anaerotignum | 0.27 ± 0.38 | 0.28 ± 0.27 | 0.09 ± 0.11 | 0.035 | 0.019 | |
| Coprobacter | 0.07 ± 0.16 | 0.14 ± 0.25 | 0.01 ± 0.02 | 0.159 | 0.001 | |
| Atopobium | 0.06 ± 0.07 | 0.02 ± 0.03 | 0.39 ± 0.77 | 0.272 | 0.038 | |
| Sigmoid colon |
Agathobaculum | 0.48 ± 0.31 | 0.70 ± 0.68 | 0.23 ± 0.33 | 0.071 | 0.045 |
| Sporobacter | 0.37 ± 0.47 | 0.17 ± 0.26 | 0.06 ± 0.11 | 0.001 | 0.017 | |
| Anaerotignum | 0.24 ± 0.34 | 0.27 ± 0.26 | 0.12 ± 0.16 | 0.236 | 0.029 | |
| Anaerococcus | 0.03 ± 0.05 | 0.01 ± 0.04 | 0.08 ± 0.13 | 0.583 | 0.014 | |
| Feces | Alistipes | 0.92 ± 1.20 | 1.69 ± 1.49 | 0.34 ± 0.41 | 0.118 | 0.018 |
| Parasutterella | 0.72 ± 1.07 | 0.26 ± 0.37 | 0.06 ± 0.12 | 0.026 | 0.024 | |
| Klebsiella | 0.42 ± 1.10 | 0.49 ± 1.54 | 0.02 ± 0.03 | 0.461 | 0.022 | |
| Odoribacter | 0.16 ± 0.19 | 0.20 ± 0.18 | 0.08 ± 0.13 | 0.135 | 0.011 | |
| Anaerotignum | 0.15 ± 0.19 | 0.28 ± 0.37 | 0.08 ± 0.11 | 0.311 | 0.031 | |
| Coprobacter | 0.05 ± 0.13 | 0.14 ± 0.16 | 0.01 ± 0.02 | 0.086 | 0.009 |
CH, chronic hepatitis; HCV, hepatitis C virus; LC, liver cirrhosis; Ctrl, control; SD, standard deviation; SVR, sustained virologic response. * Mann–Whitney U test.