TABLE 1.

Gait analysis in Drd2^I212F mice.

Results are shown for selected measures of gait obtained using a DigiGait treadmill. Time measurements (swing, time spent swinging the limb forward; propel, time spent in propulsion with the paw pushing backward; brake) are in milliseconds, length measurements (stride length; stance width) are in centimeters, and stride frequency is strides per second. A spreadsheet with the data for 42 measures of gait, including the seven shown here, is available in the Supplemental material (raw digigait data.xlsx).

	Swing Time	Propel Time	Brake Time	Propel/Brake	Stride Freq.	Stride Length	Stance Width
Forelimbs
WTa	94 ± 4	93 ± 5	65 ± 4	1.63 ± 0.16	4.07 ± 0.09	6.07 ± 0.13	1.5 ± 0.07
Het	109 ± 2***	100 ± 3c	62 ± 3	1.71 ± 0.09	3.78 ± 0.07**	6.49 ± 0.15b	1.6 ± 0.04
I212F	109 ± 3**	114 ± 4**	56 ± 3	2.19 ± 0.21b	3.63 ± 0.06***	6.72 ± 0.10***	1.5 ± 0.06
ANOVA	F (2,73) = 9.9	F (2,70) = 8.8	F (2,73) = 1.7	F (2,73) = 3.5	F (2,73) = 7.8	F (2,73) = 7.5	F (2,35) = 0.39
	P = 0.0002	P = 0.0004	P = 0.19	P = 0.035	P = 0.0009	P = 0.001	P = 0.68
Hind Limbs
WT	98 ± 3	110 ± 5	36 ± 2	3.10 ± 0.14	4.20 ± 0.09	5.85 ± 0.11	3.0 ± 0.07
Het	107 ± 3	126 ± 3**	40 ± 2	3.49 ± 0.23	3.76 ± 0.06***	6.54 ± 0.09***	2.8 ± 0.04
I212F	101 ± 3	136 ± 4***	41 ± 2	3.62 ± 0.32	3.71 ± 0.09***	6.67 ± 0.13***	2.9 ± 0.05
ANOVA	F (2,73) = 2.53	F (2,73) = 10.9	F (2,73) = 1.19	F (2,73) = 1.26	F (2,73) = 12.2	F (2,73) = 15.7	F (2,35) = 1.97
	P = 0.087	P < 0.0001	P = 0.31	P = 0.29	P < 0.0001	P < 0.0001	P = 0.154

^aWT, Drd2^+/+; Het, Drd2^+/I212F; I212F, Drd2^I212F/I212F.

^bP < 0.05; **P < 0.01; ***P < 0.001 compared with Drd2^+/+ mice.

^cP < 0.05 compared with Drd2^I212F/I212F.