Fig. 3A, B.
Effect of combination treatment with α-TOS and DCs on established 3LL tumors. Mice were injected s.c. with 106 3LL tumor cells. Established tumors (~30 mm3) were injected (i.p. or i.t.) with NaS or α-TOS on days 10, 14, and 18 (indicated by double arrows on x-axis). The mice were next injected with 106 immature DCs (i.t.) on days 12, 16, and 20 (indicated by single arrows on x-axis). A The tumor volumes of six individual mice per group. Untreated mice, mice injected with NaS alone, DCs alone, or with NaS+DCs were euthanized on day 24 due to high tumor burden. Mice injected with either α-TOS or α-TOS+DCs were euthanized on day 30. Down arrow indicates death of a mouse in the group due to high tumor burden. B Data are mean tumor volumes ± SEM