Fig. 1.

Antitumor activity of Virulizin. C8161 cells (1×10⁷ cells in 100 μl of PBS) were subcutaneously injected into the right flank of CD-1 nude mice. The mice were then administered intraperitoneally with 0.2 ml of saline or Virulizin daily when tumors reached a volume of 50–100 mm³. Tumor dimension was periodically measured using calipers over a 4-week period. Each point represents average volume calculated from ten mice. Bars SE. Inset a day after the last treatment, tumors were excised from the animals, and tumor weight was measured. Antitumor activity was estimated by the reduction of tumor weight. The data are representative of three independent experiments.