Table 1.
Side effects in cynomolgus monkeys treated with DT388IL3 intravenously for up to six every other day doses
| Dose (μg/kg every other day IV×6) | |||||
|---|---|---|---|---|---|
| 100 | 100 | 150 | 150 | Control | |
| Toxicity | 7228 | 7229 | 7225a | 7226b | 7227 |
| Hematology | |||||
| Leukopenia | 0 | 0 | 0 | 0 | 0 |
| Leukocytosis | 1 | 0 | 3 | 2 | 1 |
| Thrombocytopenia | 0 | 0 | 1 | 2 | 0 |
| Anemia | 2 | 3 | 2 | 3 | 2 |
| Gastrointestinal/appetite | |||||
| Anorexia | 1 | 1 | 3 | 3 | 0 |
| Weight loss | 0 | 0 | 1 | 0 | 0 |
| Diarrhea | 0 | 0 | 1 | 1 | 0 |
| Liver | |||||
| Alanine transferase elevation | 0 | 1 | 2 | 2 | 0 |
| Hypoalbuminemia | 2 | 2 | 3 | 2 | 0 |
| Renal/metabolic | |||||
| Elevated blood urea nitrogen | 0 | 0 | 0 | 0 | 0 |
| Elevated creatinine | 0 | 0 | 0 | 0 | 0 |
| Hypokalemia | 0 | 0 | 1 | 1 | 0 |
| Overall health | |||||
| Activity level | 0 | 0 | 3 | 2 | 0 |
| Discomfort/malaise | 1 | 1 | 3 | 3 | 0 |
Uckun toxicity grading system with grades 0–3 (0 within normal limits, 1 mild, 2 moderate, 3 severe)
aThrough three doses
bThrough five doses