Table 2.
Histopathological findings of cynomolgus monkeys treated with DT388IL3 intravenously for up to six every other day doses
Histopathological findings | 100 ug/kg dose group | 150 ug/kg dose group | |||
---|---|---|---|---|---|
#7228 | #7229 | #7225 | #7226 | #7227 | |
Hepatocellular swelling | 1 | 1 | 1 | 1 | |
Extramedullary hematopoeisis | 1 | 1 | 1 | 2 | |
Myeloid hyperplasia | 1 | 1 | 2 | 3 | |
Lymphoplasmacytic gastritis or colitis | 1 | 1 | 1 | ||
Lymphoid depletion, spleen | 1 | 1 | |||
Lymphoid follicular hyperplasia | 2 | 2 |
1 mild, 2 moderate, 3 marked, 4 severe