Table 2.

Toxicity of L612 HuMAb administration

Patient	Dose and number of courses	Infusion ratea (per hour)	Toxicityb
			First infusion	Second infusion	Third infusion
1	960 mg (473 mg/m2)	20 mg	NS	–	–
2	960 mg (612 mg/m2)	20 mg	Tumor pain	–	–
3	960 mg (593 mg/m2)×2c	20 mg	Pruritus/rash	NS	–
4	1,440 mg (911 mg/m2)×2c	30 mg	NS	NS	–
5	1,440 mg (727 mg/m2)	30 mg	Pruritus/rash	–	–
6	1,440 mg (692 mg/m2)×2c	30 mg	Pruritus/rash	NS	–
7	1,920 mg (753 mg/m2)×2c	40 mg	Pruritus/rash	NS	–
8	1,920 mg (1,060 mg/m2)	40 mg	NS	–	–
9	1,920 mg (1,223 mg/m2)×3c	40 mg	Pruritus/rash	Pruritus/rash	Pruritus/rash

^aContinuous infusion for 48 h

^b NS, not significant; itching/rash were mild and transient

^cPatients 3, 4, 6, 7, and 9 received a second infusion with the same dose 5, 44, 7, 4 and 5 weeks, respectively, after the first infusion. Patient 9 received a third infusion with the same dose 14 weeks after the second infusion