Fig. 5.

NK cells are required for antitumor effects of FCs. NK cells were depleted by administering antiasialo GM1 into mice given injections of B16 cells and FCs. On days 0 and 7, FC/B16 were subcutaneously inoculated into the flank. Subsequently, on day 14, B16 cells were inoculated into the same flank. Antiasialo GM1 was injected i.p. on days −1, 3, 7, and 10. The antitumor effect was reduced in mice depleted of NK cells compared with the controls (n=5 in each group)