Fig. 5.

Hierarchical clustering of probe sets differentially expressed in vaccinated as opposed to nt mice. Probe sets were converted in virtual two-dye experiments by comparing all replicates of each group with the wk2pgr replicates. Virtual two-dye experiments of wk6nt, wk10nt, wk15vax, wk22pb and wk26vax, grouped by hierachical clustering, yielded five gene clusters characterizing the experimental groups. a Cluster strongly down-regulated in wk6nt and wk10nt mice, and encompassing three casein isoforms and WAP. b Cluster mainly up-modulated in Triplex-vaccinated mice and encompassing two chemokine genes, two MHC II antigens and one T-cell-specific GTPase. c Cluster with many “stromal” genes (protocollagens, actins and elastins) mainly expressed in wk6nt mice. d Cluster containing IFN-induced genes, up-modulated almost solely in triplex-vaccinated mice. e Cluster containing only Ig chain genes.