Fig. 3.

Id-specific TCR-transgenic SCID mice are protected against Id⁺ MOPC315. TCR-transgenic SCID and SCID littermates were injected s.c. with either Id⁺ MOPC315 or Id⁻ J558 and observed for tumor development. An Id-specific tumor protection was observed since protection required Id-specific transgenes as well as Id expression by the tumor. Since Id-specific TCR-transgenic SCID mice lack B cells and CD8⁺ T cells, and since their CD4⁺ T cells only express the transgenic TCR and not endogenous TCR chains, Id-specific CD4⁺ T cells protect against tumor development. Protection could be transferred with purified CD4⁺ T cells to SCID recipients [9]. This Figure is redrawn from Fig. 3 in [9] with permission from the publishers