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Receptors for IL-13 and IL-4. IL-4 and IL-13 share the type II IL-4R, which shares the IL-4Rα chain with the type I IL-4R as well. Both receptors use JAK1 and Stat6 for signal transduction, but differ in JAK2 and JAK3. The receptors also have different distributions among cell and tissue types. An additional high affinity receptor for IL-13, IL-13Rα2, has no known function at this time, but has served as a component of a soluble IL-13 inhibitor. See [16, 43] for more detailed treatment
