Fig. 2A–C.

Molecular modeling of the HLA-A2 molecule complexed with E75 altered peptide ligands. The HLA-A2 antigen alpha helices are displayed in red (left: α1 domain, right: α2 domain) and the beta sheet in yellow. A HLA-A2-E75. B HLA-A2-APL 2; amino acids different from wild-type E75 are denoted by a change from blue to green. C HLA-A2-APL 5; Glu⁴ is represented by the black residue. The same orientation was used for all HLA-A2/peptide complexes