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Recombinant IL-1α, IL-6, and GM-CSF decrease CD80 costimulatory molecule expression. Regressor cell lines B6D8-4scid and B6C3-4scid were treated for 48 h with exogenous cytokines IL-1α (5,000 pg/ml), IL-6 (250 and 500 pg/ml), and GM-CSF (5,000 or 10,000 pg/ml). Stimulation of B6C3-4scid cell line resulted in significant decreases in CD80 expression; while stimulation of the cell line B6D8-4scid did not. Results are from four independent experiments
