Figure 1.

The research hypothesis of p75^NTR modulation in ischemic stroke in mice.

Pharmacological modulation of p75^NTR using LM11A-31 or genetically knocking down p75^NTR improves the outcome of ischemic stroke in mice through reducing cerebral infarction, cerebral edema, hemorrhage, and inflammation. Also, it promoted neuronal survival and neuroprotection. Created with BioRender.com. ERK1/2: Extracellular signal-related kinase 1/2; GSK3: glycogen synthase kinase 3β; JNK: c-Jun N-terminal kinase; NF-κB: nuclear factor-κB; p75^NTR: p75 neurotrophin receptor; TNF-α: tumor necrosis factor-α.