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. 2023 Dec 15;19(10):2290–2298. doi: 10.4103/1673-5374.390958

Figure 7.

Figure 7

LbGP decreases the mRNA expression of pro-inflammatory cytokines in the MNU-injured retina.

(A–F) mRNA expression of the indicated pro-inflammatory cytokines in each group. LbGP significantly reduced the MNU-induced upregulation of nuclear factor (NF)-κB and hypoxia-inducible factor (HIF)-1, but not the other cytokines, in the retinas of photoreceptor-degenerative mice. Data expressed as mean ± standard error of the mean (Con, n = 3; MNU, n = 4; LbGP, n = 4); *P < 0.05, **P < 0.01 (one-way analysis of variance followed by Tukey’s post hoc test). CD40: Tumor necrosis factor receptor superfamily 5; Con: C57BL/6J mice; HIF-1: hypoxia-inducible factor-1; iNOS: inducible nitric oxide synthase; IL-1β: interleukin-1 beta; IL-6: interleukin-6; LbGP: N-methyl-N-nitrosourea-injured mice with Lycium barbarum glycopeptide treatment; MNU: N-methyl-N-nitrosourea-injured mice without treatment; NF-κB: nuclear factor kappa-B.