Fig 4. Evaluation on the strength of literature evidence supporting the target candidates identified by different methods.

(A)-(B), The numbers of target-disease associations among the top-200 predictions with C_r values, i.e., co-occurrence frequencies, greater than 0, 5, and 25, respectively, for the comparisons of Progeni with different baselines (A) and the four control models (B), respectively. (C)-(D), The Spearman correlations between the top-k (k = 200, 500, 1000, 1500, 2000, 2500, and 3000) prediction scores and their corresponding C_r values, for the comparisons of Progeni with different baselines (C) and the four control models (D), respectively. All results were summarized over ten trials and expressed as mean ± SD.