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. Author manuscript; available in PMC: 2025 May 1.
Published in final edited form as: J Invest Dermatol. 2023 Dec 9;144(5):1071–1074.e6. doi: 10.1016/j.jid.2023.11.009

Figure 1. TWEAK induces inflammatory activity in human keratinocytes relevant for AD.

Figure 1.

(A-D) RNA-seq of human keratinocytes with triplicate cell cultures stimulated with human TWEAK, IL-13, or IL-22. (A-B) Venn diagram of upregulated transcripts that are AD specific (A) or common to both AD and psoriasis (B). (C-D) Heatmaps of a select subset of TWEAK upregulated transcripts that are also found upregulated in the skin lesions of AD patients categorized either as AD-specific transcripts (C) or commonly upregulated in AD and psoriasis (D). (E) Heatmaps showing the z-score transformed values of mean percentage of keratinocytes that were positive (i.e., have non-zero gene expression in single-cell data) for genes associated with TWEAK activity (left) and the average expression for each gene (right) from healthy controls, untreated AD patients, or dupilumab-treated AD patients. AD; Atopic dermatitis.