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. Author manuscript; available in PMC: 2025 May 1.
Published in final edited form as: J Invest Dermatol. 2023 Dec 9;144(5):1071–1074.e6. doi: 10.1016/j.jid.2023.11.009

Figure 2. TWEAK combined with IL-13 or IL-22 synergistically upregulates and downregulates multiple AD-related gene transcripts in keratinocytes.

Figure 2.

RNA-seq of human keratinocytes with triplicate cell cultures stimulated with TWEAK and IL-13 or TWEAK and IL-22. (A) Heatmap showing the expression patterns of the 66 synergistically upregulated AD genes induced by TWEAK and IL-13. (B) Heatmap showing the expression patterns of the 17 synergistically upregulated AD genes induced by TWEAK and IL-22. (C) Heatmap showing the expression patterns of the 51 AD genes synergistically downregulated by TWEAK and IL-13. (D) Heatmap showing the expression patterns of the 75 AD genes synergistically downregulated by TWEAK and IL-22. AD; Atopic dermatitis.