Table 1.

Summary of trials evaluating the clinical effect dexmedetomidine in one-lung ventilation.

Study (sample size)	Country	Surgery	Dexmedetomidine dose		Type of anesthesia	Ventilatory settings			Lung resection
			Loading dose	Infusion rate		TV	PEEP	FiO2
Shi et al. (n = 120) [19]	China	Open	None	0.5 μg/kg/h	TIVA	7 mL/kg	N/A	N/A	N/A
Xie et al. (n = 116) [21]	China	VATS	1 μg/kg	0.3 μg/kg/h	TIVA	6 mL/kg	3 cmH2O	100%	Lobectomy
Meng et al. (n = 40) [18]	China	VATS	1 μg/kg	0.5 μg/kg/h	TIVA	6–8 mL/kg	5 cmH2O	100%	Lobectomy
Zhang et al. (n = 56) [22]	China	N/A	1 μg/kg	0.5 μg/kg/h	Inhaled	6 mL/kg	5 cmH2O	N/A	N/A
Wu et al. (n = 60) [20]	Taiwan	VATS	None	0.5 μg/kg/h	Inhaled	5 mL/kg	5 cmH2O	50%	Lobectomy
Jannu et al. (n = 80) [15]	India	VATS	1 μg/kg	0.5 μg/kg/h	Inhaled	N/A	N/A	N/A	Lob, Segm, Wedge
Lee et al. (n = 50) [16]	Korea	VATS	1 μg/kg	0.5 μg/kg/h	Inhaled	6 mL/kg	3 cmH2O	60%	Lobectomy
Zhu et al. (n = 67) [24]	China	VATS	1 μg/kg	0.5 μg/kg/h	TIVA	6 mL/kg	N/A	80%	Lob, Segm, Wedge
Lee et al. (n = 100) [17]	Korea	VATS	None	1 μg/kg	Inhaled	N/A	N/A	N/A	Lob, Segm, Wedge
Zhou et al. (n = 112) [23]	China	N/A	1 μg/kg	0.3 μg/kg/h	N/A	N/A	N/A	N/A	N/A
Guo et al. (n = 124) [14]	China	N/A	1 μg/kg	0.4 μg/kg/h	TIVA	N/A	N/A	N/A	N/A
Fan et al. (n = 50) [13]	China	VATS	1 μg/kg	0.5 μg/kg/h	Inhaled	6 mL/kg	N/A	60%	Lobectomy