Table 3.
Two-sample Mendelian Randomization estimates of air pollution-related methylation on CRC risk.
| Exposure | CpG site | CpG.Chr | CpG.Pos | Nearest gene | Method | SNP | OR (95% CI) | P value | FDR |
|---|---|---|---|---|---|---|---|---|---|
| PM2.5 | cg13835894 | 2 | 219,148,914 | TMBIM1/PNKD | IVW | rs1870123, rs876961 | 1.19 (1.12, 1.27) | 5.04E-09 | 4.43E-06 |
| cg16235962 | 11 | 118,754,507 | CXCR5 | Wald ratio | rs497916 | 1.54 (1.27, 1.88) | 1.15E-05 | 0.005 | |
| NO2 | cg16947394 | 3 | 52,930,628 | TMEM110 | Wald ratio | rs11708390 | 1.57 (1.30, 1.89) | 1.88E-06 | 0.004 |
Chr, chromosome; Pos, position; OR, odds ratio, CRC risk per SD change in DNA methylation at air pollution related CpG sites in blood; 95% CI, 95% confidence interval; IVW, inverse variance weighted.