Figure 3.

Overlaying IFNγ^−/−myeloid cells improved the MASH liver in SHP^Δhepmice. A: Liver TG content was lower in Δhep_Con’ than fl/fl_Con’ mice and was not significantly changed by the ablation of IFNγ in myeloid cells in either sex. B: Liver cholesterol content was not different between genotypes and treatments in both sexes. C. Liver F4/80⁺ cells were increased by the hepatic deletion of SHP and were reduced by the ablation of IFNγ in myeloid cells in both sexes. D. Quantification of Masson's trichrome blue staining showed that liver collagen content was not changed by the hepatic deletion of SHP and was suppressed by overlaying IFNγ^−/− myeloid cells in both sexes. E. Representative images of Masson's trichrome blue staining from different groups (n = 6, scale bar in each image equals 100 um). Statistical analysis was performed with 2-way ANOVA with Tukey's multiple comparisons. ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗∗, p < 0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)