Skip to main content
. 2023 Dec 30;14(4):100931. doi: 10.1016/j.jpha.2023.12.021

Fig. 2.

Fig. 2

Alteration of gut taxa in immune-complex glomerulonephritis (ICGN) rats after two weeks of cationic bovine serum albumin challenge. (A) Changes in α-diversity indices, including Chao1, observed species, Shannon, and Simpson index, between sham and ICGN rats. (B) A significant difference was observed in β-diversity (principal component analysis ( (PCoA)) based on the unweighted (Adonis, P = 0.004) but not weighted (Adonis, P = 0.086) UniFrac between the sham and ICGN rats. (C) Taxonomic distribution at phylum level between ICGN and sham rats by 16S ribosomal DNA (rDNA) sequencing. (D) Taxonomic distribution at the genus level between ICGN and sham rats by 16S rDNA sequencing. (E) The Firmicutes to Bacteroidetes (F/B) ratio at the phylum level. (F) Differential taxa of intestinal microbiota in sham and ICGN rats by linear discriminant analysis (LDA) effect size (LEfSe) analysis. P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001 by analysis of variance (ANOVA) (n = 10). PC: principal component.