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. 2023 Oct 23;42(8):1282–1295. doi: 10.1038/s41587-023-01964-9

Extended Data Fig. 7. Additional signal in cells containing multiple guides in a conventional 1,130 gene Perturb-seq screen in mouse BMDCs.

Extended Data Fig. 7

These cells would normally be discarded before analysis. (a) Correlation of top 10,000 estimated effects with held-out validation (y-axis) when varying cell count (x-axis). (b) Increase in effective sample size in cells (y-axis) when including cells containing 2 or 3 guides (x-axis). Effective sample size for cells with 2 or 3 guides is computed as the number of single-guide containing cells needed to achieve the same held-out validation accuracy (from a).