Table 2.

Case reports about LIT in patients with renal impairment

Study	Age	Gender	Infection	Linezolid initial dose	Dose reduction	Renal function	Thrombocytopenia	Outcome
Cossu et al., 2014 [5]	72	Woman	MRSA pulmonary infection	600 mg b.i.d.	Discontinuation	CRRT	32*10^9/L	Thrombocytes reached normal levels 7 days after discontinuation
Tsuji et al., 2015 [9]	78	Man	MRSA mediastinitis	600 mg o.d.	300 mg o.d.	8.6 mL/min/1.73 m2	65*10^9/L	Thrombocyte count recovered and infection was successfully treated with linezolid
Taguchi et al., 2013 [11]	87	Woman	MRSA	1200 mg/day	600 mg o.d.	30 mL/min	54*10^9/L	Decreased dose was well tolerated, no thrombocytopenia occurred
Xiao et al., 2018 [23]	50	Woman	MRSA endocarditis	600 mg b.i.d.	None	23 mL/min/1.73 m2	12*10^9/L	Died from multiple organ failure

b.i.d. bis in die = twice a day, CRRT continuous renal replacement therapy, o.d. omne in die = once a day