Table 3.
Description of primary and secondary pharmacokinetic parameters
| Parameters | Description |
|---|---|
| Cmax | Maximum concentration |
| AUCt | Area under the plasma concentration-time curve from time zero to the last time of quantifiable concentration |
| AUC∞ | Area under the plasma concentration-time curve from time zero extrapolated to infinity |
| Tmax | Time to reach maximum concentration |
| tlag | Lag time. The observation time before the first measurable blood concentration was observed |
| t½z | Terminal elimination half-life. |
| Vz/F | Apparent volume of distribution |
| CLz/F | Apparent clearance |
| λz | Elimination rate constant |
| AUC_%Extrap | Residual area percentage |