Table 5.
Analysis of variance results of pharmacokinetic parameters after logarithmic transformation in healthy subjects after oral administration of globalagliatin 80 mg
| Parameter | Variation | f-value | p-value |
|---|---|---|---|
| Cmax (N = 24) | Sequence | 0.016 | 0.900 |
| Cycle | 2.668 | 0.117 | |
| Administration conditions | 9.037 | 0.007 | |
| AUCt (N = 24) | Sequence | 0.016 | 0.899 |
| Cycle | 4.071 | 0.056 | |
| Administration conditions | 37.390 | < 0.001 | |
| AUC∞ (N = 24) | Sequence | 0.007 | 0.936 |
| Cycle | 4.155 | 0.054 | |
| Administration conditions | 37.778 | <0.001 |
Cmax maximum concentration, AUCt area under the plasma concentration-time curve from time zero to time of the last quantifiable concentration, AUC∞ area under the plasma concentration-time curve from time zero extrapolated to infinity